October 7, 2025
I simply obtained again from London, the place I used to be interviewed on stage on the Well being Optimisation Summit.
On the eight-hour flight over, I spent my time scribbling down some contemporary biohacks and rising traits I’ve been experimenting with recently—the sort that (A) really transfer the needle on efficiency, well being, longevity, and biomarkers, and (B) I haven’t actually shared a lot about but.
Need an insider glimpse of my notes?
Then preserve studying, as a result of I’ve obtained ten juicy bits for you.
1. The GLP-1 Revolution: Past Weight Loss to Metabolic Mastery
The story of glucagon-like peptide-1 (GLP-1) receptor agonists has been one of the crucial dramatic developments in metabolic well being this yr.
Whereas most individuals know them as weight reduction medication, rising analysis exhibits systemwide advantages nicely past the size.
Current research have demonstrated vital advantages past urge for food and glycemic management, together with lowered main adversarial cardiovascular occasions, with semaglutide displaying a 26% decrease threat of dying from cardiovascular causes, nonfatal myocardial infarction, or nonfatal stroke, and a 20% discount in main adversarial cardiac occasions in sufferers with chubby or weight problems.
GLP-1 medicines, past decreasing blood sugar and physique weight, present broad protecting results throughout a number of programs, lowering dangers of cardiovascular and kidney illness whereas additionally bettering outcomes in situations linked to weight problems and metabolic dysfunction. It highlights their position in extending advantages past kind 2 diabetes to coronary heart failure, liver illness, sleep apnea, osteoarthritis, and peripheral artery illness. Take a look at the total research right here.
The cardiovascular advantages are significantly compelling.
In March 2024, the FDA permitted a label growth for Wegovy to cut back the danger of cardiovascular dying, coronary heart assault, and stroke in adults with heart problems and weight problems or chubby.
This represents a paradigm shift in how metabolic medicines are seen—not simply as weight administration instruments, however as potential cardiovascular protecting brokers.
What makes GLP-1 receptor agonists significantly attention-grabbing is their multifaceted mechanism of motion. They improve insulin secretion and scale back glucagon ranges, leading to superior glycemic management in comparison with conventional kind 2 diabetes therapies.
Moreover, their gastric emptying results contribute to sustained satiety, naturally decreasing caloric consumption with out the psychological wrestle and metabolic rebound usually seen in restrictive weight-reduction plan approaches.
The lipid profile enhancements are equally spectacular, with vital reductions in low-density lipoprotein (LDL) ldl cholesterol and triglycerides that compound the cardiovascular advantages.
Maybe most intriguingly, rising analysis suggests potential advantages for non-alcoholic fatty liver illness (NAFLD) and diabetic kidney illness, indicating systemic metabolic optimization reasonably than focused symptom administration.
However right here’s what’s most vital…
To avert problematic points like gastrointestinal uncomfortable side effects, muscle loss, and nausea, you must think about microdosing (try this podcast for extra info), reasonably than utilizing the usual GLP-1 doses.
I’m not a health care provider, and this isn’t medical recommendation, however smaller doses of a GLP-1 agonist can nonetheless ship spectacular results, one thing I first realized once I interviewed Dr. Tyna Moore (you possibly can try the total present right here).
For instance, I at the moment use a Monday, Wednesday, Friday dose of 0.25mg retatrutide, which is technically a triple-agonist that targets three pathways: glucagon, GLP-1, and gastric inhibitory polypeptide, injected 3 times per week, however since retatrutide is changing into more durable to get, I’ll most likely change to 0.25mg tirzepatide quickly (Peptual is my peptide supply).
These small doses give me the metabolic results of those spectacular peptides, however not a lot urge for food suppression that I can’t do issues like eat satisfactory protein and carry heavy weights.
2. Ketone Physique Optimization: The D-BHB and L-BHB Configuration Revolution
The ketone physique panorama has advanced approach past fasting, carb restriction, and exogenous ketone supplementation.
The rising analysis on particular beta-hydroxybutyrate (BHB) configurations—significantly the excellence between D-BHB and L-BHB ketones—has opened new frontiers in metabolic optimization and neuroprotection, and I’ve been sucking down BHB ketones like sweet with unbelievable focus, urge for food satiating, and efficiency outcomes.
Whereas they give the impression of being fairly related, nearly like mirror photographs of one another, D-BHB is the metabolically energetic type of the ketone beta-hydroxybutyrate, whereas L-BHB is a much less energetic, slower-metabolizing precursor.
Within the physique, D-BHB is extra effectively transformed to adenosine triphosphate (ATP), whereas L-BHB serves primarily as a signaling molecule and is excreted in urine. Merchandise containing a mix of D- and L-BHB, referred to as “racemic mixtures,” can result in a extra sustained however decrease ketone focus in comparison with D-BHB alone.
The determine illustrates how ketone our bodies are produced and used: D-3-hydroxybutyrate (D-3-HB) is shaped within the liver by way of the HMG-CoA pathway and oxidized in extrahepatic tissues to generate acetyl-CoA for the Krebs cycle, whereas L-3-hydroxybutyrate (L-3-HB), synthesized via much less well-defined pathways, is imported into mitochondria, activated to L-3-hydroxybutyryl-CoA, after which metabolized to acetyl-CoA, with ketone our bodies additionally serving as precursors for lipid and ldl cholesterol synthesis. See the total research.
For instance, a latest randomized, double-blind, placebo-controlled research confirmed that each day consumption of D-BHB can promote weight reduction, particularly via fats discount, however the advantages of D-BHB prolong far past physique composition.
Analysis additionally exhibits that D-BHB ketones improve glutamate-mediated stimulation of respiration in comparison with glucose, and allow stronger and extra sustained uncoupled respiration, principally that means enhanced mitochondrial operate on the mobile degree.
The neuroprotective results of are additionally fairly compelling…
D-BHB’s capability to inhibit one thing referred to as the “NLRP3 inflammasome” represents a direct anti-inflammatory mechanism that protects in opposition to neurodegenerative processes. This pathway might be essential for cognitive longevity and will clarify the cognitive enhancement many individuals, together with me, report with therapeutic ketosis.
From a cardiovascular perspective, D-BHB supplementation persistently demonstrates enhancements in LDL ldl cholesterol profiles whereas lowering triglycerides and blood stress. The oxidative stress discount in cardiac cells suggests protecting results that might compound over time with constant use.
Current analysis exhibits that D-BHB supplementation is protected and well-tolerated, inducing a gentle rise in blood ketones whereas suppressing lipolysis and lowering exercise-induced metabolic stress markers. This means potential functions for train restoration and metabolic flexibility enhancement.
The muscle preservation results throughout caloric restriction signify one other vital profit, probably permitting for extra aggressive fats loss phases with out the everyday lean mass sacrifice. This makes ketone supplementation significantly helpful for physique recomposition objectives.
Enjoyable truth: On the Well being Optimisation Summit, I had the privilege of saying from the stage the upcoming launch of the world’s first edible ketone bar—the Boundless Bar.
Every bar delivers a scientifically formulated dose of probably the most highly effective ketone, D-BHB, designed to gasoline the physique and mind with clear, environment friendly vitality. And since ketones are notoriously tough to make palatable, we labored tirelessly to create indulgent flavors that actually style unbelievable: Vanilla Cheesecake, Cinnamon Roll, Chocolate-Chip Cookie Dough, and (coming quickly) Blueberry Pie.
The brand new ketone-packed Boundless Bars are actually formally out there right here!
3. Excessive-Dose Creatine: Redefining the Higher Limits of Supplementation
The panorama of creatine supplementation is shifting as new analysis highlights the advantages of upper dosing protocols that transcend conventional tips.
For years, the usual method has been 3–5 grams per day. Nonetheless, mounting proof suggests that considerably bigger doses can ship extra benefits throughout a number of physiological programs.
For instance, a loading part of 20–25 grams per day can quickly saturate muscle creatine shops. This acceleration enhances ATP availability, resulting in measurable enhancements in power, energy output, and dash efficiency—typically by 5–15%.
Utilizing larger doses of creatine may allow you to see outcomes sooner and unlock advantages past muscle efficiency. Analysis additionally exhibits that, when accomplished short-term (30 g/day for five–7 days), these protocols are typically well-tolerated. The uncomfortable side effects are often minor (like momentary water retention or gentle abdomen discomfort).
The cognitive enhancement results of higher-dose creatine are significantly intriguing, as nicely.
Dosing ranges of 8-20 grams each day have demonstrated enhancements in working reminiscence, processing pace, and psychological readability, particularly underneath situations of stress or sleep deprivation, suggesting that mind phosphocreatine shops could require larger systemic availability to realize therapeutic ranges.
On this research, members took both creatine or a placebo at 8:30 p.m. in two separate periods spaced at the least 5 days aside, with seven beginning on creatine first and eight beginning on placebo. Measurements have been taken at 6 p.m. (earlier than dosing) after which once more at midnight, 2 a.m., and 4 a.m., every session lasting about 95 minutes and together with mind scans, fatigue rankings, reaction-time checks, and different cognitive duties. For the mind imaging, researchers used particular spectroscopy scans: three small ¹H-MRS voxels and two ³¹P-MRS grids positioned in numerous mind areas. These scans tracked energy-related indicators like phosphocreatine (PCr), inorganic phosphate (Pi), ATP, whole creatine, N-acetyl-aspartate (NAA), and neurotransmitters equivalent to glutamate and glutamine. See the research right here.
Neuroprotective functions signify an rising frontier. The flexibility to raise mind phosphocreatine ranges via supplementation may defend in opposition to traumatic mind harm and will have functions in neurodegenerative illness prevention. The vitality buffer impact in neural tissue might be significantly helpful for people engaged involved sports activities or high-risk actions.
As well as, the bone well being implications of high-dose creatine supplementation have been underappreciated.
Analysis signifies elevated osteoblast exercise and enhancements in bone mineral density, significantly when mixed with resistance coaching. This represents a dual-pathway method to skeletal well being that might be particularly helpful for getting old populations.
Apparently, latest analysis has targeted on the experimental use of intranasal creatine administration to ship creatine to the mind (in animal fashions).
However I wouldn’t strive it: intranasal creatine administered in a lab setting to a rodent is approach totally different than snorting powdered creatine, which may trigger extreme respiratory irritation and irritation.
The usual and protected methodology of creatine supplementation is oral ingestion. Even for that, in the event you go the high-dose creatine route, cut up it into doses of not more than 5g at a time and keep hydrated (until you wish to threat a shock catastrophe in your pants).
4. Thoracic Mobility: The Basis of Your Core Efficiency
In my very own mobility program—which consists of 15–20 minutes of energetic stretching, foam rolling, and mobility every morning (demonstrated right here)—thoracic backbone mobility has emerged as one of the crucial underappreciated but elementary points of the way in which my physique feels and performs all day.
The thoracic area serves because the cornerstone of correct motion patterns, respiratory effectivity, and neural operate, making its optimization important for anybody severe about peak efficiency.
The postural implications of thoracic mobility prolong far past simply aesthetics. Correct thoracic extension and rotation instantly affect cervical backbone positioning, shoulder mechanics, and lumbar backbone loading patterns. This creates a cascade impact the place thoracic limitations manifest as ache and dysfunction all through the kinetic chain.
Respiratory operate enhancements stands out as the most instantly impactful advantage of enhanced thoracic mobility.
Elevated rib cage flexibility permits for larger diaphragmatic tour and enhanced lung growth capability. This interprets to improved oxygen supply, extra environment friendly respiratory patterns, and enhanced parasympathetic nervous system activation.
The athletic efficiency functions of fine thoracic mobility are in depth, as nicely.
Sports activities requiring rotational energy—golf, tennis, swimming—rely closely on thoracic backbone mobility for optimum drive technology and switch. Restricted thoracic rotation forces compensatory motion patterns that scale back energy output and improve harm threat.
Listed here are three good, easy-to-learn, thoracic mobility workouts that concentrate on the commonest restriction patterns:
- Foam Curler Thoracic Extensions: Sit along with your knees bent and a foam curler behind your mid-back. Lace your palms behind your head, preserve your butt on the bottom, and gently lean again over the curler. Maintain for 10 seconds (you possibly can comply with this instance).
- Quadruped Thoracic Rotation: From a crawl place in your palms and knees, place one hand behind your head and rotate your thoracic backbone via a full vary of movement (see this instance to strive it your self).
- World’s Biggest Stretch Thoracic Opener: From a plank or modified plank, step your proper foot ahead outdoors your proper hand. Carry your proper hand, rotate your chest open, and attain towards the ceiling. Decrease your hand again down and repeat. Change sides and carry out the identical motion on the left (right here is an effective demonstration).
These easy strikes goal frequent restriction patterns whereas offering quick suggestions for correct execution and development.
5. Pre-Exercise Chilly Plunge: Dr. Thomas Seager’s Protocol Revolution
The timing of chilly publicity has been revolutionized by the work of Dr. Thomas Seager and others who’ve recognized pre-workout chilly plunging as probably superior to post-workout protocols for particular diversifications.
This represents a elementary shift in how one can make the most of chilly thermogenesis for efficiency optimization, and I used to be intrigued when Dr. Seager proposed to me on a latest podcast (you possibly can verify that out right here) that I chilly plunge pre-workout, which has additionally been talked about to me a few years prior by creator Brad Kearns.
Dr. Seager’s notes on pre-workout chilly publicity (you will discover his e-book right here) have revealed outstanding testosterone manufacturing advantages, with documented will increase of as much as 400 factors when chilly publicity is adopted by train. This hormonal optimization creates a compound impact by way of which a cold-induced stress response is amplified by subsequent bodily exercise.
The advantages of pre-workout chilly publicity embrace:
I’ve a Morozko Forge chilly plunge (designed by Dr. Seager) that I keep at 34°F. Earlier than I hit the fitness center within the morning, I now get within the plunge for two–3 minutes pre-workout. It’s a game-changer—simply be sure that to not do any biomechanically advanced workouts with heavy weights whilst you’re nonetheless shivering.
6. Molecular Hydrogen: Inhaling and Bathing
Molecular hydrogen remedy has emerged as one of the crucial promising therapeutic interventions, with experimental and scientific research displaying potential advantages for cardiovascular, respiratory, and metabolic issues, in addition to mind and nervous system issues.
The distinctive properties of molecular hydrogen, because the smallest gasoline molecule, permit for unprecedented mobile penetration and systemic availability.
I’ve accomplished a number of podcasts on molecular hydrogen, together with:
- Is This Like Consuming HUNDREDS of Bottles Of Hydrogen In A Single Sitting? The Large Antioxidant Advantages of *Inhaling* Hydrogen, With Dr. Tyler LeBaron & Alex Tarnava.
- Every thing You Want To Know About How To Use Hydrogen Water: Timing, Dosing, Supply Mechanisms, Hydrogen Tablets, Hydrogen Water Machines, Hydrogen Inhalers & A lot Extra!
- Every thing You Want To Know About Consuming HYDROGEN (Tablets vs. Bottles, When To Drink, How Hydrogen Works & A lot Extra!) With Alex Tarnava
- The 30-12 months-Previous Scientist Phenom Who Runs a 2:30 Marathon, Deadlifts 420 Kilos & Drinks Hydrogen Enriched Water.
- The Electrolyte & Mineral Replenishment Technique Closest To Human Plasma, How To “Bathe In Hydrogen,” Nasty Water Trade Myths & Truths & A lot Extra With Robert Slovak.
The Advantages of Molecular Hydrogen
Hydrogen regulates cell dying via bidirectional results on apoptosis, autophagy, and pyroptosis, lowering extreme programmed cell dying throughout irritation whereas selling these processes to exert antitumor results. Right here is the total research.
The antioxidant mechanisms of molecular hydrogen are significantly intriguing…
For the reason that 2007 discovery that molecular hydrogen has selective antioxidant properties, a number of research have proven useful results in various animal fashions and human illness. In contrast to broad-spectrum antioxidants that may intervene with useful oxidative processes, hydrogen selectively neutralizes dangerous reactive oxygen species whereas preserving important mobile signaling.
A 2024 overview discovered that hydrogen water confirmed promise in lowering fatigue and growing endurance, indicating direct efficiency advantages past therapeutic functions. The anti-inflammatory results happen via a number of pathways, together with cytokine modulation and inflammasome inhibition.
New inhalation protocols with molecular hydrogen—like these I talk about on this podcast with Dr. Tyler LeBaron and Alex Tarnava—ship fast systemic hydrogen with near-immediate bioavailability at excessive but protected doses.
The flexibility to realize therapeutic tissue concentrations inside minutes of inhalation makes this supply methodology significantly enticing for acute functions or pre-activity optimization. I now use the Inhale H2 machine that Tyler and Alex designed—merely respiratory H2 via a face masks for 30-60 minutes whereas I’m studying, meditating, or napping.
Bathing in hydrogen-rich water (you possibly can try extra info right here) is one other novel supply mechanism that provides distinctive transdermal absorption alternatives.
The pores and skin’s barrier operate permits selective hydrogen penetration whereas sustaining protecting properties. This supply methodology gives sustained publicity and will be significantly useful for inflammatory pores and skin situations.
For this, I’ve been utilizing the hydrogen tub setup developed by Lumati, and about 4 occasions per week, I atone for books, studying, podcasts, and even emails whereas I’m submerged in a transdermal hydrogen tub.
By the way in which, regardless that I now inhale and bathe with hydrogen, I nonetheless take it orally within the morning by dropping a couple of hydrogen tabs in my large morning metal jug of water.
7. Gentle and Sound Remedy: Consciousness Hacking Via Audio-Visible Entrainment
Gentle-sound remedy, AKA “audio-visual entrainment (AVE) units,” can reliably induce particular brainwave states and a few fairly spectacular physiological adjustments that considerably simulate a psychedelic or entheogenic expertise (suppose magic mushrooms or LSD-like states), however drug-free.
At residence, I take advantage of a tool referred to as the “roXiva” (podcast right here), and once I journey, the “NeuroVIZR” as types of consciousness optimization expertise with out the biochemical value (and arguably relying on dosage, the religious value) of plant medicines.
You’ll be able to try my ideas on plant medicines beneath:
These brainwave entrainment units function via one thing referred to as a “frequency-following response,” wherein exterior rhythmic stimuli information neural oscillations towards goal frequencies. This permits for exact management over states of consciousness and may facilitate entry to useful brainwave patterns which may in any other case require getting actually excessive on medication or years of meditation observe.
For instance, theta state induction (4-8 Hz) via light-sound remedy can create optimum situations for deep relaxation, emotional processing, and inventive visualization. The flexibility to reliably entry theta states has profound implications for stress administration, trauma processing, and inventive problem-solving.
As well as, alpha frequency stimulation (8-12 Hz) enhances focus, cognitive operate, and psychological readability. This represents a non-pharmaceutical method to cognitive enhancement that may be exactly calibrated to your wants and preferences.
Sleep optimization functions make the most of delta frequency focusing on (0.5-4 Hz) to advertise deeper, extra restorative sleep patterns. Common use of delta-targeting protocols may assist regulate circadian rhythms and enhance sleep high quality with out pharmaceutical intervention.
Even ache administration functions with light-sound remedy have proven spectacular outcomes, with some research indicating as much as 76% discount in persistent ache signs. The mechanisms doubtless contain disruption of ache signaling
pathways and activation of endogenous ache modulation programs.
The “sober psychedelic” experiences produced by these programs present entry to altered states of consciousness with out pharmaceutical intervention. This creates alternatives for private exploration, new thought patterns, and so-called “consciousness growth” inside a managed and protected setting.
At residence, I take advantage of my roXiva lamp for 20–60 minutes on afternoons once I want deep rest, or for fast 5–10 minute periods to spark creativity and focus. An 11-minute session on a NeuroVIZR works extremely once I’m touring and have to duck out throughout a busy convention or work day.
Should you haven’t messed round with light-sound remedy but, and also you need a drug-free, quick psychological state shift, I undoubtedly advocate making an attempt it.
8. Carbon Dioxide Remedy: Optimizing a Misunderstood Gasoline
Anders Olsson makes use of the CardiHaler to optimize athletic skills and efficiency.
Carbon dioxide remedy represents one of the crucial neglected but probably highly effective interventions in a biohacking arsenal
Whereas CO2 is often seen as a waste product, therapeutic functions make the most of its profound physiological results on oxygen supply, circulation, and nervous system operate.
I used to be first launched to this remedy once I interviewed Anders Olsson (you possibly can try that present right here) in regards to the multitude of advantages of CO2 remedy, and have been utilizing his CardiHaler machine at my desk for a number of months, which consists of a fast 5-10 minute burst of respiratory 5–7% CO2 whereas I’m checking emails or writing.
The “Bohr Impact” mechanism is central to CO2 remedy’s advantages. Managed will increase in CO2 ranges improve hemoglobin’s capability to launch oxygen to tissues, successfully bettering mobile oxygenation regardless of unchanged oxygen saturation ranges. This creates a pathway to enhanced mobile vitality manufacturing and metabolic optimization.
Vasodilation results happen via CO2’s direct motion on easy muscle in blood vessel partitions. This pure mechanism gives enhanced circulation to muscular tissues, mind, and organs with out pharmaceutical intervention. The improved microcirculation has implications for restoration, cognitive operate, and cardiovascular well being.
The nervous system modulation results of therapeutic CO2 publicity embrace activation of parasympathetic pathways and enchancment in coronary heart price variability. This may create a pure stress discount response that may complement different rest and restoration protocols.
Athletic efficiency functions leverage each the improved oxygen supply and enhanced circulation to spice up endurance and speed up restoration.
The mixture of higher mobile oxygenation and enhanced waste product elimination creates optimum situations for sustained high-intensity efficiency, so that is additionally one thing you possibly can fiddle with pre-workout.
Cognitive advantages additionally happen via elevated cerebral blood movement, with analysis displaying as much as 54.5% will increase with managed CO2 publicity. This enhanced mind circulation interprets to improved psychological readability, focus, and cognitive processing pace.
9. Plasma Alternative Remedy: Mobile Rejuvenation Via Younger Blood Elements
Plasma substitute remedy (which is considerably totally different from therapeutic plasma alternate, or TPE) represents a frontier of regenerative medication, using the concentrated regenerative components present in younger plasma to reverse getting old processes and restore mobile operate.
This intervention targets the basic mechanisms of getting old on the systemic degree, and in comparison with all of the gene therapies, blood filtrations, stem cells, and different fancy protocols I’ve accomplished, it’s most likely the largest game-changer I’ve ever skilled for feeling like I’ve wound again the clock to eighteen years outdated.
I did a complete podcast about my expertise wth plasma substitute remedy at Austin Regenerative Remedy (you possibly can hearken to it right here), however the primary science is that this: small extracellular vesicles (sEVs) and exosomes in younger plasma carry particular microRNAs that instantly stimulate mitochondrial biogenesis and improve mobile vitality manufacturing. These signaling molecules can restore youthful mobile operate by activating pathways that turn out to be suppressed with getting old.
The progress components current in younger plasma can present a direct stimulus for tissue restore and regeneration. In contrast to artificial progress components, plasma-derived components work synergistically and embrace cofactors needed for optimum organic exercise.
Younger blood has been proven to cut back aging-related signs, help cell progress and restore, restrict persistent irritation and fibrosis, and even reverse age-related gene expression throughout 51 cell sorts from 20 main organs and tissues in older animals. Overview the research right here.
Cytokine modulation via younger plasma remedy helps restore steadiness to inflammatory pathways that turn out to be dysregulated with getting old. This creates a systemic anti-inflammatory setting that helps tissue upkeep and restore processes.
The signaling molecules in younger plasma additionally facilitate improved cell-to-cell communication, which deteriorates with getting old and contributes to lack of tissue coordination and performance. Restoration of those communication pathways may have profound implications for systemic rejuvenation.
You most likely noticed Bryan Johnson (you possibly can try our present collectively right here) doing this remedy in his documentary, Don’t Die.
Whereas I didn’t use my very own son’s plasma, my expertise at Austin Regenerative Remedy concerned two days of getting 18—25-year-old wholesome male donor plasma infused into my physique by way of ten IV luggage.
I understand {that a} protocol like this sounds just like the area of maximum biohackers and longevity-seeking billionaires, however as I discussed, it’s most likely probably the most notable biohack I’ve ever tried by way of how I instantly regarded, felt, and carried out. The outcomes have included ongoing muscle acquire (I used to be 185 kilos once I did the process and am now 202 kilos, with no change in physique fats) and a change in my pores and skin look that has led numerous individuals to ask about my “new skincare” protocol.
However I haven’t accomplished something totally different, aside from the younger plasma remedy…
From what I perceive, Texas is the one state the place this process is even authorized, so if you wish to do it, then you possibly can contact Austin Regenerative Remedy.
10. Prayer: The Final “Biohack” for Nervous System Optimization
Prayer creates measurable adjustments in nervous system operate and total physiology.
For instance, prayer naturally reduces respiration price and will increase exhalation period, creating an optimum respiratory sample for parasympathetic nervous system activation. This stunned me to be taught, however this transformation in breath sample happens routinely with out aware respiratory management.
In a podcast interview with Dr. Andrew Huberman (you possibly can hearken to it right here), Dr. David DeSteno described that vagal tone enhancements throughout prayer trigger enhanced parasympathetic “rest-and-digest” operate and improved autonomic steadiness.
Increased vagal tone is related to higher stress resilience, improved coronary heart price variability, and enhanced restoration capability.
The cortisol discount results of prayer present direct stress hormone optimization. A daily prayer observe has been proven to assist keep more healthy baseline cortisol ranges and enhance your physique’s stress response patterns over time.
The psychological security sign generated by prayer observe indicators to your mind that the setting is safe, even when praying about nerve-racking conditions. This creates a novel alternative to course of difficult experiences inside a physiologically calm state.
In fact, the obvious cause this happens is since you’re casting your cares and worries upon a better energy (God) and deeply realizing that you simply aren’t having to struggle by yourself, no matter battle you’re combating.
Cardiovascular advantages of prayer embrace lowered coronary heart price and blood stress that happen throughout prayer, indicating precise physiological rest reasonably than merely psychological consolation. These results appear to contribute to long-term cardiovascular well being when prayer is practiced repeatedly.
In fact, the accessibility of prayer makes it one of the crucial sensible methods out there. No tools, particular coaching, or monetary funding is required, but the physiological advantages rival these of lots of the extra refined technological interventions I’ve described on this article.
Unsure the place to start out?
My method is easy: in addition to prayers of gratitude earlier than every meal, a morning household prayer assembly throughout our each day household huddle, and consistently speaking to God all through the day (significantly throughout nerve-racking conditions or earlier than large choices), I personally have a Notes app on my iPhone the place I preserve a unique prayer that I pray every morning of the week.
I’ve developed many of those prayers via inspiration from creator John Eldredge, whom I interviewed right here, and who additionally has a superb checklist of prayers at the Wild At Coronary heart web site prayer checklist web page.
Integration and Implementation—Constructing Your Private Biohacking Protocol
The true energy of those interventions doesn’t essentially lie of their particular person utility however of their synergistic integration as potential “stacks” you possibly can weave right into a day or week.
If you mix the precise instruments, you don’t simply get incremental positive aspects—you create a synergy that amplifies vitality, restoration, resilience, and longevity.
Listed here are some highly effective examples of how these stacks will be constructed:
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Metabolic Optimization Stack: Begin with GLP-1 help to improve systemic metabolic operate, add ketone supplementation to gasoline neurological and cardiovascular efficiency, and layer in high-dose creatine to maximise mobile vitality output. This mixture addresses a number of points of metabolic well being concurrently.
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Restoration and Adaptation Protocol: Combine pre-workout chilly plunging for hormonal optimization, molecular hydrogen remedy for oxidative stress administration, and thoracic mobility work for motion high quality enhancement to create a complete method to coaching adaptation and restoration.
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Consciousness and Stress Technique: Mix gentle and sound remedy to dial in brainwave states, add CO₂ coaching to stabilize your nervous system, and end with prayer or meditation to anchor psychological resilience. That is the place cutting-edge tech meets historic knowledge, creating a strong toolkit for stress mastery.
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Regenerative Longevity Method: Use hydrogen, delivered transdermally or via inhalation, for deep mobile rejuvenation, mix it with plasma substitute remedy for a systemic “oil change,” and reinforce it with thoracic mobility practices to keep up long-term operate. This stack isn’t about slowing getting old—it’s about rewiring your biology for longevity.
In fact, 2025 is way from over…
I’m certain that via books, podcast visitors, conferences, and my continued give attention to immersive journalism, analysis, and self-guinea-pigging, I’ll uncover loads extra biohacks to share with you.
However within the meantime, be happy to depart your feedback beneath. I’m curious: which of those game-changing approaches will you implement first, and which do you may have questions on?
